Comparative Evaluation of Efficacy of Jati Ghrita and 1% Chlorhexidine Gluconate on Aphthous Stomatitis- A Research Protocol for Randomised Control Trial

Abstract

Introduction: Aphthous ulcer is seen to be one of the most commonly occurring ailments found among patients that dentists may come across on a daily basis. Taking into consideration, the agents that have been used for treatment of Aphthous stomatitis safety, least toxic properties with symptomatic relief and topical application are considered. These days there are few reliable natural remedies which are emerging as a therapy for aphthae. Herbal and polyherbal medicines will alleviate pain, induce healing, prevent infection and lessen inflammation in aphthous ulcers without any adverse effects. Aim: To evaluate and compare the efficacy of Jati Ghrita and 1% chlorhexidine gluconate on aphthous stomatitis patients. Materials and Methods: A randomised control trial will be carried out for an expected time of 3-4 months, in the Department of Oral Medicine and Radiology, Sharad Pawar Dental College and Dattatray Ayurvedic Rasashala, Wardha, Maharashtra, India. The study population consisting of 30 patients (age 18-65 years) with Aphthous stomatitis will be divided randomly into two groups i.e., Jati Ghrita and 1% Chlorhexidine gluconate, each group consisting of 15 patients. Efficacy will be assessed by patient’s response through Visual Analogue Scale (VAS) and oral physician’s observation-5 point Investigator’s Global Assessment (IGA) scale. The intergroup comparison will be done by independent sample t-test. Expected Results: Jati Ghrita is expected to be effective in faster healing of aphthous stomatitis with reduction in pain. Jati is also expected to be more effective than 1% chlorhexidine gluconate. Conclusion: Hence, this study will evaluate and compare the efficacy of Jati Ghrita and 1% chlorhexidine gluconate on aphthous stomatitis