Disease Burden of Hepatitis B Infection and Section Vaccination Trends in Healthcare Workers: A Prospective Cohort Study

Abstract

Introduction: Hepatitis B Virus (HBV) infection is an important occupational hazard for Healthcare Workers (HCWs), with an approximately four-fold increased risk of acquiring this infection compared to the normal population. The horizontal mode of transmission is the predominant mode among HCWs. Additionally, vaccination trends among HCWs have been disappointing, with paramedics reported to have a higher risk of HBV transmission and receiving HBV vaccination less often than doctors. Aim: To determine the burden of hepatitis B infection and vaccination trends among HCWs. Materials and Methods: This cross-sectional study was conducted at Pandit Bhagwat Dayal Sharma PGIMS, Rohtak Haryana, India, from March 2019 to January 2020, enrolling 250 HCWs. The study included 80 junior residents, 17 house surgeons, 123 nursing staff, 18 Laboratory Technicians (LTs), and 12 Operation Theatre Assistants (OTAs). The subjects were divided into two groups: medical workers (Group-1; House Surgeons and Junior Residents) and paramedical workers (Group-2; Nursing staff, LTs, OTAs). The sample size was calculated using Probability Proportion to Size (PPS) of HCWs. Descriptive statistics were performed. Results: None of the subjects tested positive for Hepatitis B surface Antigen (HBsAg) during the study period. A total of 196 (78.4%) subjects were vaccinated, while 54 (21.6%) subjects remained Non-Vaccinated (NV). Out of the 196 vaccinated subjects, 140 (71.4%) were Completely Vaccinated (CV), and 56 (28.6%) were Incompletely Vaccinated (IV). The vaccination rate was highest among junior residents (95%) and lowest among LTs and OTAs (50%). Among the 80 junior residents, 76 (95%) were vaccinated, and 4 (5%) were NV. Among the 123 nursing staff, 89 (72.3%) were vaccinated, and 34 (27.7%) were CV, 9 (50%) were NV and 3 were in category of IV. Among the 18 LTs, 6 (33.3%) were CV, and 9 (50%) were NV. None of the 12 OTAs were CV, with 6 (50%) being NV. Conclusion: HCWs are at a potential risk of contracting HBV infection as an occupational hazard. There is need to strengthen efforts towards vaccination and prevention of HBV infection.