Pharmacokinetic and Pharmacodynamic Modifiers of EF5 Uptake and Binding

Author:

Koch Cameron J.,Evans Sydney M.

Publisher

Society of Nuclear Medicine

Subject

Radiology Nuclear Medicine and imaging

Reference7 articles.

1. Comparison of the Hypoxia PET Tracer 18F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models

2. Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules

3. Koch CJ, Lord EM, inventors; Trustees of University of Pennsylvania, University of Rochester, assignee. Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts. U.S. patent 5540908. July 30, 1996.

4. Koch CJ Evans SM . Optimizing hypoxia detection and treatment strategies. Semin Nucl Med. In press.

5. Koch CJ . The reductive activation of nitroimidazoles; modification by oxygen and other redox-active molecules in cellular systems. In: Adams GE, Breccia A, Fielden EM, Wardman P, eds. Selective Activation of Drugs by Redox Processes. New York, NY: Plenum Press; 1990:237–247.

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