Author:
Iwata Shigeru,Tanaka Yoshiya
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease that causes multiple organ damage in women of childbearing age and has a relapsing-remitting course. SLE is caused by the interaction between genetic and environmental factors, however, its underlying triggers remain unknown. Among the environmental factors, the involvement of infections as a trigger for SLE, especially those of viral etiology, has been widely reported. Human endogenous retroviruses (HERVs) may put patients at a genetic predisposition to SLE, while the Epstein-Barr virus (EBV) may play a role as an environmental factor that triggers the development of SLE. It has been suggested that EBV-infected B-cells may become resistant to apoptosis, resulting in the activation, proliferation, and antibody production of autoreactive B-cells, which cause tissue damage in SLE. However, the interaction between the virus and immune cells, as well as the impact of the virus on the differentiation and dysfunction of immune cells, remain unclear. In this review, we focus on the relationship between the development and pathogenesis of SLE and viral infections, as well as the mechanism of SLE exacerbation via activation of immune cells, such as B-cells, based on the latest findings.
Reference109 articles.
1. State-of-the-art treatment of systemic lupus erythematosus;Tanaka;Int J Rheum Dis.,2020
2. Current mechanistic insights into the role of infection in systemic lupus erythematosus;Pan;Biomed Pharmacother.,2019
3. From anti-EBV immune responses to the EBV diseasome via cross-reactivity;Kanduc;Glob Med Genet.,2020
4. Molecular mimicry, genetic homology, and gene sharing proteomic “molecular fingerprints” using an EBV (Epstein-Barr Virus)-derived microarray as a potential diagnostic method in autoimmune disease;Dreyfus;Immunol Res.,2018
5. The possible effect of B-cell epitopes of epstein-barr virus early antigen, membrane antigen, latent membrane protein-1, and−2A on;Tu;Systemic Lupus Erythematosus Front Immunol.,2018
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