Abstract
IntroductionInflammation plays a significant role in gallstones formation. The prognosis of various illnesses was initially predicted using the systemic immune-inflammatory index (SII). We performed an updated analysis on the impact of SII and gallstones.MethodsTo investigate the connection between the SII and gallstones occurrence in a sample of individuals from the National Health and Nutrition Examination Survey (NHANES) database from 2017 to 2020, we employed logistic regression analysis, subgroup analysis, and smoothing curve fitting.ResultsIn our study, an aggregate of 4,950 individuals over the age of 20 were enrolled, and 429 of them claimed to have gallstones. A fully adjusted model showed that the third and fourth quartiles of SII was parallel associated with gallstones in adults (OR = 2.43, 95% CI = 1.39–4.26; OR = 2.97, 95% CI = 1.72–5.16) under 50 years. Subgroup analysis and smoothed curve fitting provided evidence in favor of this finding.ConclusionAccording to our research, gallstones are more likely to occur in US adults younger than 50 years.