Author:
Cui Wenying,Yan Junling,Weng Wenjia,Gao Yanqing,Zhu Wei
Abstract
BackgroundIn recent years, the incidence of syphilis has increased year by year. Our study is to explore the risk factors for the development of neurosyphilis in patients who failed syphilis treatment.MethodsA total number of 165 patients with complete medical records and who agreed to undergo lumbar puncture were divided into 47 neurosyphilis cases and 118 non-neurosyphilis cases according to the diagnostic criteria of neurosyphilis, and the differences in clinical characteristics and laboratory features between the two groups were analyzed. Significant variables were entered into multivariable logistic regression models.Results(1) There were statistical differences (p < 0.05) between the neurosyphilis (NS) group and the non-neurosyphilis (NNS) group in terms of the higher proportion of male and serum rapid plasma reagin (RPR) > 1:32 and the elevated cerebrospinal fluid white blood cell (CSF WBC) and CSF protein in the neurosyphilis group compared with the non-neurosyphilis group. (2) Male gender, serum RPR titers >1:32 at lumbar puncture, CSF WBC >8 × 106/L were significantly associated with neurosyphilis.ConclusionFor patients who have failed syphilis treatment, lumbar puncture should be performed to exclude neurosyphilis, to enable early diagnosis and treatment, and to prevent irreversible damage of neurosyphilis, especially if the patient is male and has a serum RPR>1:32 and elevated CSF WBC at lumbar puncture, which are risk factors for neurosyphilis.
Reference21 articles.
1. Factors associated with syphilis treatment failure and reinfection: a longitudinal cohort study in Shenzhen, China;Luo;BMC Infect Dis.,2017
2. CXCL13 concentration in latent syphilis patients with treatment failure;Zhang;Open Med.,2020
3. Sexually transmitted diseases treatment guidelines, 2010;Workowski;MMWR Recomm Rep.,2010
4. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents;Kaplan;MMWR Recomm Rep,2009
5. Guidelines for diagnosis and treatment of syphilis, gonorrhea and genital Chlamydia trachomatis infection;Chin J Dermatol.,2020
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