Intelligent diagnosis system based on artificial intelligence models for predicting freezing of gait in Parkinson’s disease

Abstract

IntroductionFreezing of gait (FoG) is a significant issue for those with Parkinson’s disease (PD) since it is a primary contributor to falls and is linked to a poor superiority of life. The underlying apparatus is still not understood; however, it is postulated that it is associated with cognitive disorders, namely impairments in executive and visuospatial functions. During episodes of FoG, patients may experience the risk of falling, which significantly effects their quality of life.MethodsThis research aims to systematically evaluate the effectiveness of machine learning approaches in accurately predicting a FoG event before it occurs. The system was tested using a dataset collected from the Kaggle repository and comprises 3D accelerometer data collected from the lower backs of people who suffer from episodes of FoG, a severe indication frequently realized in persons with Parkinson’s disease. Data were acquired by measuring acceleration from 65 patients and 20 healthy senior adults while they engaged in simulated daily life tasks. Of the total participants, 45 exhibited indications of FoG. This research utilizes seven machine learning methods, namely the decision tree, random forest, Knearest neighbors algorithm, LightGBM, and CatBoost models. The Gated Recurrent Unit (GRU)-Transformers and Longterm Recurrent Convolutional Networks (LRCN) models were applied to predict FoG. The construction and model parameters were planned to enhance performance by mitigating computational difficulty and evaluation duration.ResultsThe decision tree exhibited exceptional performance, achieving sensitivity rates of 91% in terms of accuracy, precision, recall, and F1- score metrics for the FoG, transition, and normal activity classes, respectively. It has been noted that the system has the capacity to anticipate FoG objectively and precisely. This system will be instrumental in advancing consideration in furthering the comprehension and handling of FoG.