Liver fibrosis and MAFLD: the exploration of multi-drug combination therapy strategies

Author:

Dong Qingfu,Bao Haolin,Wang Jiangang,Shi Wujiang,Zou Xinlei,Sheng Jialin,Gao Jianjun,Guan Canghai,Xia Haoming,Li Jinglin,Kang Pengcheng,Xu Yi,Cui Yunfu,Zhong Xiangyu

Abstract

In recent years, the prevalence of metabolic-associated fatty liver disease (MAFLD) has reached pandemic proportions as a leading cause of liver fibrosis worldwide. However, the stage of liver fibrosis is associated with an increased risk of severe liver-related and cardiovascular events and is the strongest predictor of mortality in MAFLD patients. More and more people believe that MAFLD is a multifactorial disease with multiple pathways are involved in promoting the progression of liver fibrosis. Numerous drug targets and drugs have been explored for various anti-fibrosis pathways. The treatment of single medicines is brutal to obtain satisfactory results, so the strategies of multi-drug combination therapies have attracted increasing attention. In this review, we discuss the mechanism of MAFLD-related liver fibrosis and its regression, summarize the current intervention and treatment methods for this disease, and focus on the analysis of drug combination strategies for MAFLD and its subsequent liver fibrosis in recent years to explore safer and more effective multi-drug combination therapy strategies.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Heilongjiang Province

Beijing Xisike Clinical Oncology Research Foundation

Science Fund for Distinguished Young Scholars of Xinjiang Autonomous Region

Publisher

Frontiers Media SA

Subject

General Medicine

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