Author:
Roy-Vallejo Emilia,Fernández De Córdoba-Oñate Sara,Delgado-Wicke Pablo,Triguero-Martínez Ana,Montes Nuria,Carracedo-Rodríguez Rosa,Zurita-Cruz Nelly,Marcos-Jiménez Ana,Lamana Amalia,Galván-Román José María,Villapalos García Gonzalo,Zubiaur Pablo,Ciudad Marianela,Rabes Laura,Sanz Marta,Rodríguez Carlos,Villa Almudena,Rodríguez Jesús Álvarez,Marcos Celeste,Hernando Julia,Díaz-Fernández Paula,Abad Francisco,de los Santos Ignacio,Rodríguez Serrano Diego A.,García-Vicuña Rosario,Suárez Fernández Carmen,P. Gomariz Rosa,Muñoz-Calleja Cecilia,Fernández-Ruiz Elena,González-Álvaro Isidoro,Cardeñoso Laura,
Abstract
IntroductionSARS-CoV-2 viral load has been related to COVID-19 severity. The main aim of this study was to evaluate the relationship between SARS-CoV-2 viremia and SNPs in genes previously studied by our group as predictors of COVID-19 severity.Materials and methodsRetrospective observational study including 340 patients hospitalized for COVID-19 in the University Hospital La Princesa between March 2020 and December 2021, with at least one viremia determination. Positive viremia was considered when viral load was above the quantifiable threshold (20 copies/ml). A total of 38 SNPs were genotyped. To study their association with viremia a multivariate logistic regression was performed.ResultsThe mean age of the studied population was 64.5 years (SD 16.6), 60.9% patients were male and 79.4% white non-Hispanic. Only 126 patients (37.1%) had at least one positive viremia. After adjustment by confounders, the presence of the minor alleles of rs2071746 (HMOX1; T/T genotype OR 9.9 p < 0.0001), rs78958998 (probably associated with SERPING1 expression; A/T genotype OR 2.3, p = 0.04 and T/T genotype OR 12.9, p < 0.0001), and rs713400 (eQTL for TMPRSS2; C/T + T/T genotype OR 1.86, p = 0.10) were associated with higher risk of viremia, whereas the minor alleles of rs11052877 (CD69; A/G genotype OR 0.5, p = 0.04 and G/G genotype OR 0.3, p = 0.01), rs2660 (OAS1; A/G genotype OR 0.6, p = 0.08), rs896 (VIPR1; T/T genotype OR 0.4, p = 0.02) and rs33980500 (TRAF3IP2; C/T + T/T genotype OR 0.3, p = 0.01) were associated with lower risk of viremia.ConclusionGenetic variants in HMOX1 (rs2071746), SERPING1 (rs78958998), TMPRSS2 (rs713400), CD69 (rs11052877), TRAF3IP2 (rs33980500), OAS1 (rs2660) and VIPR1 (rs896) could explain heterogeneity in SARS-CoV-2 viremia in our population.