Author:
Du Jun,Shi Yan,Zhou Changming,Guo Lianying,Hu Ruiming,Huang Cheng,Hu Guoliang,Gao Xiaona,Guo Xiaoquan
Abstract
In this study, we investigated the therapeutic effect and mechanism of action of vitamin C on chronic heat stress (CHS)-induced liver oxidative damage and inflammation in laying hens. The thermoneutral control group (TN group) was kept at a constant temperature of 22 ± 1°C, while the chronic heat stress group (CHS group) and the vitamin C supplemented group (HSV group) were exposed to heat stress (HS) (36 ± 1°C, 8 h/d). The TN and HS groups were fed the basic diet at will, and the HSV group was supplemented with 300 mg/kg of vitamin C on top of the basic diet. The experimental results showed a significant improvement in body weight and feed intake in the HSV group compared to the HS group. A significantly lower pH and higher HCO3- and PCO2 levels were observed in the HSV group compared to the CHS group. As laying hens were supplemented with vitamin C, serum malondialdehyde (MDA) level was declined, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were increased, and total antioxidant capacity (T-AOC) was increased. Further, CHS induced an increase in the expression of inflammation-related genes and a decrease in the expression of antioxidant-related genes. In contrast, the addition of vitamin C reversed the effects of CHS, resulting in an increase in the expression of antioxidant-related genes and a decrease in the expression of inflammation-related genes. In conclusion, vitamin C can effectively alleviate CHS-induced acid-base imbalance in body fluids of laying hens and the oxidative damage and inflammatory response caused to the liver. Therefore, vitamin C can be used clinically as an effective drug to alleviate chronic heat stress in laying hens. This experiment provides clinical evidence and theoretical basis for the use of vitamin C as an effective drug to alleviate chronic heat stress in laying hens.
Reference62 articles.
1. Heat waves, the new normal: summertime temperature extremes will impact animals, ecosystems, and human communities;Stillman;Physiology.,2019
2. VanDerWal J. The projected effect on insects, vertebrates, and plants of limiting global warming to 15 degrees C rather than 2 degrees;Warren;C Science.,2018
3. Analysis of heat stress in UK dairy cattle and impact on milk yields;Dunn;Environ Res Lett.,2014
4. Characterizing heat stress on livestock using the temperature humidity index (Thi)—prospects for a warmer caribbean;Lallo;Reg Environ Change.,2018
5. Risk of climate-related impacts on the livestock sector: a review of the evidence;Godde;Global Food Sec,2021
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献