A new boundary growth model for the analysis of microscopic blockage and various cross-section shapes effects in porous functional medical material

Abstract

It is crucial to simulate the physical processes of blood flow in functional medical materials in order to characterize their functional properties in different scenarios. In this paper, the microscopic obstruction model of blood coagulation by functional hemostatic materials with boundary growth factor is constructed by CFD for the first time. Moreover, the effects of different inlet pressures, temperatures and material shapes on the hemostatic properties of the materials were analyzed using blood flow rate and blockage time as metrics. The researches show that: as blood flows into the material, thrombus begins to form at the boundary and progresses toward the center; smaller inlet pressures promote thrombus growth; external temperature has little effect on thrombus growth; materials possessing smaller flow rates beneficial to thrombus growth; and the larger the cross-sectional area in the material’s flow channel, the faster blood coagulates. This study provides new ideas for characterizing the performance of functional hemostatic materials and the design of hemostatic materials in different application scenarios.