Author:
Preethi A.,Bellare Jayesh R.
Abstract
Research in the orthopedic application has attracted the scientific community to design and develop advanced, engineered synthetic scaffolds that possess all the essential cues properties necessary for successful regeneration and restoration of tissue function. Despite having the best surgical practices, nosocomial infections like surgical site infections can negatively impact the outcome of the scaffolds that are intended only for regenerative purposes. Therefore, there is a need to include anti-microbial properties as one of the parameters while designing a scaffold. There are various methods implemented to tackle microbial colonization such as modifying the scaffold surface that deflects microbes from surface adhesion and modifying the scaffold surface by inactivating microbes upon contact while maintaining the biocompatibility of the scaffold and also maintaining the scaffold viable for new bone formation. This review lists various anti-microbial polymers and compounds available in nature and methods to incorporate them into the scaffold with polymer and ceramics as the base material, without compromising bioactivity. We have reviewed various anti-microbial compounds, biomaterials and have also identified various biomolecules (vitamins, phytochemicals and anti-microbial peptides) that can be utilized for orthopedic application.
Subject
Materials Science (miscellaneous)
Reference317 articles.
1. The effect of charge at the surface of silver nanoparticles on antimicrobial activity against Gram-positive and Gram-negative bacteria: a preliminary study;Abbaszadegan;J. Nanomater.,2015
2. Effects of Tinospora cordifolia (Menispermaceae) on the proliferation, osteogenic differentiation and mineralization of osteoblast model systems in vitro;Abiramasundari;J. Ethnopharmacol.,2012
3. Novel and facile microwave-assisted synthesis of Mo-doped hydroxyapatite nanorods: characterization, gamma absorption coefficient, and bioactivity;Abutalib;Mater. Sci. Eng. C.,2017
4. Antimicrobial, antioxidant, and wound healing properties of Kigelia africana (Lam.) Beneth. and Strophanthus hispidus DC;Agyare;Adv. Pharmacol. Sci.,2013
5. Antimicrobial properties of vitamin B2;Ahgilan;Int. J. Food Prop.,2016
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献