Author:
Bhagirath Anjali Y.,Medapati Manoj Reddy,de Jesus Vivianne Cruz,Yadav Sneha,Hinton Martha,Dakshinamurti Shyamala,Atukorallaya Devi
Abstract
Pregnancy is a tightly regulated immunological state. Mild environmental perturbations can affect the developing fetus significantly. Infections can elicit severe immunological cascades in the mother's body as well as the developing fetus. Maternal infections and resulting inflammatory responses can mediate epigenetic changes in the fetal genome, depending on the developmental stage. The craniofacial development begins at the early stages of embryogenesis. In this review, we will discuss the immunology of pregnancy and its responsive mechanisms on maternal infections. Further, we will also discuss the epigenetic effects of pathogens, their metabolites and resulting inflammatory responses on the fetus with a special focus on craniofacial development. Understanding the pathophysiological mechanisms of infections and dysregulated inflammatory responses during prenatal development could provide better insights into the origins of craniofacial birth defects.
Reference323 articles.
1. Transplantation immunity and the maternal-fetal relationship;Billingham;Trans Stud Coll Physicians Phila.,1964
2. Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye;Medawar;Br J Exp Pathol.,1948
3. Temporal and spatial expression of major histocompatibility complex class I H-2K in the early mouse embryo;Arcellana-Panlilio;Biol Reprod.,1994
4. Expression of H-2K major histocompatibility antigens on preimplantation mouse embryos;Warner;Biol Reprod.,1993
5. Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy;Moldenhauer;J Immunol.,2009
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