Author:
Doubliez Alice,Nio Enzo,Senovilla-Sanz Fernando,Spatharioti Vasiliki,Apps Richard,Timmann Dagmar,Lawrenson Charlotte L.
Abstract
The role of the cerebellum in emotional control has gained increasing interest, with studies showing it is involved in fear learning and memory in both humans and rodents. This review will focus on the contributions of the cerebellum to the extinction of learned fear responses. Extinction of fearful memories is critical for adaptive behaviour, and is clinically relevant to anxiety disorders such as post-traumatic stress disorder, in which deficits in extinction processes are thought to occur. We present evidence that supports cerebellar involvement in fear extinction, from rodent studies that investigate molecular mechanisms and functional connectivity with other brain regions of the known fear extinction network, to fMRI studies in humans. This evidence is considered in relation to the theoretical framework that the cerebellum is involved in the formation and updating of internal models of the inner and outer world by detecting errors between predicted and actual outcomes. In the case of fear conditioning, these internal models are thought to predict the occurrence of an aversive unconditioned stimulus (US), and when the aversive US is unexpectedly omitted during extinction learning the cerebellum uses prediction errors to update the internal model. Differences between human and rodent studies are highlighted to help inform future work.
Funder
H2020 Marie Skłodowska-Curie Actions
Deutsche Forschungsgemeinschaft
Medical Research Council
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Developmental Neuroscience,Neuroscience (miscellaneous)
Cited by
4 articles.
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