Increased usage of doxycycline for young children with Lyme disease

Author:

Thompson Amy D.,Neville Desiree N.,Chapman Laura L.,Balamuth Fran,Ladell Meagan M.,Kharbanda Anupam B.,Aresco Rachael,Nigrovic Lise E.

Abstract

BackgroundThe 2018 Infectious Disease Committee of the American Academy of Pediatrics stated that up to 3 weeks or less of doxycycline is safe in children of all ages. Our goal was to examine trends in doxycycline treatment for children with Lyme disease.MethodsWe assembled a prospective cohort of children aged 1 to 21 years with Lyme disease who presented to one of eight participating Pedi Lyme Net centers between 2015 and 2023. We defined a Lyme disease case with an erythema migrans (EM) lesion or positive two-tier Lyme disease serology categorized by stage: early-localized (single EM lesion), early-disseminated (multiple EM lesions, cranial neuropathy, meningitis, and carditis), and late (arthritis). We compared doxycycline treatment by age and disease stage and used logistic regression to examine treatment trends.ResultsOf the 1,154 children with Lyme disease, 94 (8.1%) had early-localized, 449 (38.9%) had early-disseminated, and 611 (53.0%) had late disease. Doxycycline treatment was more common for older children (83.3% ≥ 8 years vs. 47.1% < 8 years; p < 0.001) and with early-disseminated disease (77.2% early-disseminated vs. 52.1% early-localized or 62.1% late; p < 0.001). For children under 8 years, doxycycline use increased over the study period (6.9% 2015 to 67.9% 2023; odds ratio by year, 1.45; 95% confidence interval, 1.34–1.58).ConclusionYoung children with Lyme disease are frequently treated with doxycycline. Prospective studies are needed to confirm the safety and efficacy of doxycycline in children younger than 8 years, especially for those receiving courses longer than 3 weeks.

Funder

Global Lyme Alliance

Publisher

Frontiers Media SA

Reference28 articles.

1. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines;Agwuh;J. Antimicrob. Chemother.,2006

2. Effectiveness of antibiotic treatment in children with Lyme neuroborreliosis-a retrospective study;Arnason;BMC Pediatr.,2022

3. Intravenous ceftriaxone compared with oral doxycycline for the treatment of Lyme neuroborreliosis;Borg;Scand. J. Infect. Dis.,2005

4. Doxycycline for the treatment of lyme disease in young children;Brown;Pediatr. Infect. Dis. J.,2023

5. The incidence of staining of permanent teeth by the tetracyclines;Conchie;Can. Med. Assoc. J.,1970

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3