Author:
Singh Lakhveer,Roy Subhadeep,Kumar Anurag,Rastogi Shubham,Kumar Dinesh,Ansari Mohd. Nazam,Saeedan Abdulaziz S.,Singh Manjari,Kaithwas Gaurav
Abstract
Graphical AbstractMechanism of VOA and VIN to inhibit fatty acid synthesis in DMBA-induced mammary gland carcinoma of albino Wistar rats. Hypoxia-activated HIF-1α enhances lactate acidosis in the tumor microenvironment, and dysregulated pH in the tumor microenvironment activates SREBP-1c and FASN expression to speed up the fatty acid synthesis required for plasma membrane synthesis in rapidly proliferating cells. VOA- and VIN-activated PHD-2 enhanced the proteolytic degradation of HIF, thus inhibiting fatty acid synthesis. HIF-1α, hypoxia-inducible factor-1α; SREBP-1c, sterol regulatory element-binding protein-1c; FASN, fatty acid synthesis; PHD-2, prolyl hydroxylase-2.
Subject
Cell Biology,Developmental Biology
Cited by
5 articles.
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