Role of Long Non-coding RNAs on Bladder Cancer

Abstract

Graphical AbstractLncRNAs interacted with proteins in BC. (A) UCA1 interacts with C/EBPα. (B) Lnc-LBCS directly binds to hnRNPK and EZH2, and inhibits SOX2 transcription. (C) XIST-TET1-p53 pathway in BC. (D) DGCR5 promotes P21 transcription via interacting with ARID1A. (E) LSINCT5 promotes tumor progression by interacting with NCYM, and inhibiting GSK3β activity and promoting Wnt/β-catenin signaling activation. (F) GAS5 inhibits EZH2 transcription by interacting with E2F4. (G) AWPPH promotes cell proliferation, autophagy, and migration through binding to SMAD4 via EZH2. P indicates promoter. (H) LNMAT1 regulates CCL2 expression through interaction with hnRNPL. Protein-RNA interactions are important aspects of many cellular functions, and lncRNAs are involved in modulating BC through different molecular mechanisms, including binding to one or more protein partners.