M-Cadherin Is a PAX3 Target During Myotome Patterning

Author:

Esteves de Lima Joana,Bou Akar Reem,Mansour Myriam,Rocancourt Didier,Buckingham Margaret,Relaix Frédéric

Abstract

PAX3 belongs to the paired-homeobox family of transcription factors and plays a key role as an upstream regulator of muscle progenitor cells during embryonic development. Pax3-mutant embryos display impaired somite development, yet the consequences for myotome formation have not been characterized. The early myotome is formed by PAX3-expressing myogenic cells that delaminate from the dermomyotomal lips and migrate between the dermomyotome and sclerotome where they terminally differentiate. Here we show that in Pax3-mutant embryos, myotome formation is impaired, displays a defective basal lamina and the regionalization of the structural protein Desmin is lost. In addition, this phenotype is more severe in embryos combining Pax3-null and Pax3 dominant-negative alleles. We identify the adhesion molecule M-Cadherin as a PAX3 target gene, the expression of which is modulated in the myotome according to Pax3 gain- and loss-of-function alleles analyzed. Taken together, we identify M-Cadherin as a PAX3-target linked to the formation of the myotome.

Funder

AFM-Téléthon

Agence Nationale de la Recherche

Publisher

Frontiers Media SA

Subject

Cell Biology,Developmental Biology

Reference53 articles.

1. Analysis of the developmental effects of a lethal mutation in the house mouse.;Auerbach;J. Exp. Zool.,1954

2. Integrin α6β1-laminin interactions regulate early myotome formation in the mouse embryo.;Bajanca;Development,2006

3. A novel genetic hierarchy functions during hypaxial myogenesis: pax3 directly activates Myf5 in muscle progenitor cells in the limb.;Bajard;Genes Dev.,2006

4. Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells.;Bober;Dev. Camb. Engl.,1994

5. Pax3 functions in cell survival and in pax7 regulation.;Borycki;Dev. Camb. Engl.,1999

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