Author:
Jiang Mengmeng,Xiao Yanyu,E Weigao,Ma Lifeng,Wang Jingjing,Chen Haide,Gao Ce,Liao Yuan,Guo Qile,Peng Jinrong,Han Xiaoping,Guo Guoji
Abstract
Zebrafish have been found to be a premier model organism in biological and regeneration research. However, the comprehensive cell compositions and molecular dynamics during tissue regeneration in zebrafish remain poorly understood. Here, we utilized Microwell-seq to analyze more than 250,000 single cells covering major zebrafish cell types and constructed a systematic zebrafish cell landscape. We revealed single-cell compositions for 18 zebrafish tissue types covering both embryo and adult stages. Single-cell mapping of caudal fin regeneration revealed a unique characteristic of blastema population and key genetic regulation involved in zebrafish tissue repair. Overall, our single-cell datasets demonstrate the utility of zebrafish cell landscape resources in various fields of biological research.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Subject
Cell Biology,Developmental Biology
Cited by
58 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献