Author:
Li Yinchuan,Mi Panpan,Chen Xue,Wu Jiabao,Liu Xiaohua,Tang Yunge,Cheng Jinmei,Huang Yingying,Qin Weibing,Cheng C. Yan,Sun Fei
Abstract
mRNAs have been found to undergo substantial selective degradation during the late stages of spermiogenesis. However, the mechanisms regulating this biological process are unknown. In this report, we have identified Tex13a, a spermatid-specific gene that interacts with the CCR4–NOT complex and is implicated in the targeted degradation of mRNAs encoding particular structural components of sperm. Deletion of Tex13a led to a delayed decay of these mRNAs, lowered the levels of house-keeping genes, and ultimately lowered several key parameters associated with the control of sperm motility, such as the path velocity (VAP, average path velocity), track speed (VCL, velocity curvilinear), and rapid progression.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Subject
Cell Biology,Developmental Biology
Cited by
2 articles.
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