Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System

Author:

Daher Marie-Thérèse,Bausero Pedro,Agbulut Onnik,Li Zhenlin,Parlakian Ara

Abstract

Ctip2/Bcl11b is a zinc finger transcription factor with dual action (repression/activation) that couples epigenetic regulation to gene transcription during the development of various tissues. It is involved in a variety of physiological responses under healthy and pathological conditions. Its role and mechanisms of action are best characterized in the immune and nervous systems. Furthermore, its implication in the development and homeostasis of other various tissues has also been reported. In the present review, we describe its role in skin development, adipogenesis, tooth formation and cranial suture ossification. Experimental data from several studies demonstrate the involvement of Bcl11b in the control of the balance between cell proliferation and differentiation during organ formation and repair, and more specifically in the context of stem cell self-renewal and fate determination. The impact of mutations in the coding sequences of Bcl11b on the development of diseases such as craniosynostosis is also presented. Finally, we discuss genome-wide association studies that suggest a potential influence of single nucleotide polymorphisms found in the 3’ regulatory region of Bcl11b on the homeostasis of the cardiovascular system.

Funder

AFM-Téléthon

Fondation de France

Fédération Française de Cardiologie

Université Pierre et Marie Curie

Publisher

Frontiers Media SA

Subject

Cell Biology,Developmental Biology

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