Targeting N-type calcium channels in young-onset of some neurological diseases

Abstract

Graphical AbstractN-type calcium channels dysregulation and neurotransmission impairment Early-onset of neurological conditions, like Huntington’s disease, Multiple Sclerosis, and Migraine demonstrate harmful processes, such as neuroinflammation, neurodegeneration, and conditions like pain. N-type voltage-gated calcium channels are responsible for the exacerbated calcium influx that triggers neurotransmitter release.