Author:
Shi Houhui,Li Kai,Ni Yanghong,Liang Xiao,Zhao Xia
Abstract
T lymphocytes function as major players in antigen-mediated cytotoxicity and have become powerful tools for exploiting the immune system in tumor elimination. Several types of T cell-based immunotherapies have been prescribed to cancer patients with durable immunological response. Such strategies include immune checkpoint inhibitors, adoptive T cell therapy, cancer vaccines, oncolytic virus, and modulatory cytokines. However, the majority of cancer patients still failed to take the advantage of these kinds of treatments. Currently, extensive attempts are being made to uncover the potential mechanism of immunotherapy resistance, and myeloid-derived suppressor cells (MDSCs) have been identified as one of vital interpretable factors. Here, we discuss the immunosuppressive mechanism of MDSCs and their contributions to failures of T cell-based immunotherapy. Additionally, we summarize combination therapies to ameliorate the efficacy of T cell-based immunotherapy.
Funder
National Major Science and Technology Projects of China
National Natural Science Foundation of China-Nuclear Technology Innovation Joint Fund
National Science and Technology Major Project
Sichuan Province Science and Technology Support Program
Sichuan Association for Science and Technology
Subject
Cell Biology,Developmental Biology
Cited by
18 articles.
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