Author:
Xiong Zhen,Wang Qianqian,Li Wanhong,Huang Lijuan,Zhang Jianing,Zhu Juanhua,Xie Bingbing,Wang Shasha,Kuang Haiqing,Lin Xianchai,Lee Chunsik,Kumar Anil,Li Xuri
Abstract
Platelet-derived growth factor-D (PDGF-D) is highly expressed in immune cells. However, the potential role of PDGF-D in immune system remains thus far unclear. Here, we reveal a novel function of PDGF-D in activating both classical and alternative complement pathways that markedly increase chemokine and cytokine responses to promote macrophage polarization. Pharmacological targeting of the complement C3a receptor using SB290157 alleviated PDGF-D-induced neuroinflammation by blocking macrophage polarization and inhibited pathological choroidal neovascularization. Our study thus suggests that therapeutic strategies targeting both PDGF-D and the complement system may open up new possibilities for the treatment of neovascular diseases.
Subject
Cell Biology,Developmental Biology
Cited by
8 articles.
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