Author:
Zhu Ziquan,Lu Siyuan,Wang Shui-Hua,Górriz Juan Manuel,Zhang Yu-Dong
Abstract
Aims: Most blood diseases, such as chronic anemia, leukemia (commonly known as blood cancer), and hematopoietic dysfunction, are caused by environmental pollution, substandard decoration materials, radiation exposure, and long-term use certain drugs. Thus, it is imperative to classify the blood cell images. Most cell classification is based on the manual feature, machine learning classifier or the deep convolution network neural model. However, manual feature extraction is a very tedious process, and the results are usually unsatisfactory. On the other hand, the deep convolution neural network is usually composed of massive layers, and each layer has many parameters. Therefore, each deep convolution neural network needs a lot of time to get the results. Another problem is that medical data sets are relatively small, which may lead to overfitting problems.Methods: To address these problems, we propose seven models for the automatic classification of blood cells: BCARENet, BCR5RENet, BCMV2RENet, BCRRNet, BCRENet, BCRSNet, and BCNet. The BCNet model is the best model among the seven proposed models. The backbone model in our method is selected as the ResNet-18, which is pre-trained on the ImageNet set. To improve the performance of the proposed model, we replace the last four layers of the trained transferred ResNet-18 model with the three randomized neural networks (RNNs), which are RVFL, ELM, and SNN. The final outputs of our BCNet are generated by the ensemble of the predictions from the three randomized neural networks by the majority voting. We use four multi-classification indexes for the evaluation of our model.Results: The accuracy, average precision, average F1-score, and average recall are 96.78, 97.07, 96.78, and 96.77%, respectively.Conclusion: We offer the comparison of our model with state-of-the-art methods. The results of the proposed BCNet model are much better than other state-of-the-art methods.
Subject
Cell Biology,Developmental Biology
Reference47 articles.
1. Microscopic Nuclei Classification, Segmentation and Detection with Improved Deep Convolutional Neural Network (DCNN) Approaches;Alom;arXiv preprint arXiv:1811.03447,2018
2. Low Cost Classification Method for Differentiated White Blood Cells Using Digital Image Processing and Machine Learning Algorithms;Begambre,2021
3. Machine Learning to Predict Occult Nodal Metastasis in Early Oral Squamous Cell Carcinoma;Bur;Oral Oncol.,2019
4. Label-free Discrimination and Selection of Cancer Cells from Blood during Flow Using Holography-Induced Dielectrophoresis;Dudaie;J. Biophotonics,2020
5. Feasibility Study of Stain-free Classification of Cell Apoptosis Based on Diffraction Imaging Flow Cytometry and Supervised Machine Learning Techniques;Feng;Apoptosis,2018
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献