Author:
Zhang Chunyu,Guo Lirui,Su Zhongzhou,Luo Na,Tan Yinqiu,Xu Pengfei,Ye Liguo,Tong Shiao,Liu Haitao,Li Xiaobin,Chen Qianxue,Tian Daofeng
Abstract
The tumor immune microenvironment (TIME) has been recognized to be associated with sensitivity to immunotherapy and patient prognosis. Recent research demonstrates that assessing the TIME patterns on large-scale samples will expand insights into TIME and will provide guidance to formulate immunotherapy strategies for tumors. However, until now, thorough research has not yet been reported on the immune infiltration landscape of glioma. Herein, the CIBERSORT algorithm was used to unveil the TIME landscape of 1,975 glioma observations. Three TIME subtypes were established, and the TIMEscore was calculated by least absolute shrinkage and selection operator (LASSO)–Cox analysis. The high TIMEscore was distinguished by an elevated tumor mutation burden (TMB) and activation of immune-related biological process, such as IL6-JAK-STAT3 signaling and interferon gamma (IFN-γ) response, which may demonstrate that the patients with high TIMEscore were more sensitive to immunotherapy. Multivariate analysis revealed that the TIMEscore could strongly and independently predict the prognosis of gliomas [Chinese Glioma Genome Atlas (CGGA) cohort: hazard ratio (HR): 2.134, p < 0.001; Gravendeel cohort: HR: 1.872, p < 0.001; Kamoun cohort: HR: 1.705, p < 0.001; The Cancer Genome Atlas (TCGA) cohort: HR: 2.033, p < 0.001; the combined cohort: HR: 1.626, p < 0.001], and survival advantage was evident among those who received chemotherapy. Finally, we validated the performance of the signature in human tissues from Wuhan University (WHU) dataset (HR: 15.090, p = 0.008). Our research suggested that the TIMEscore could be applied as an effective predictor for adjuvant therapy and prognosis assessment.
Funder
Health and Family Planning Commission of Hubei Province
Subject
Cell Biology,Developmental Biology
Reference84 articles.
1. Flow cytometric characterization of tumor-associated macrophages in experimental gliomas.;Badie;Neurosurgery,2000
2. Vascular endothelial growth factor secretion by tumor-infiltrating macrophages essentially supports tumor angiogenesis, and IgG immune complexes potentiate the process.;Barbera-Guillem;Cancer Res.,2002
3. Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology.;Bardy;Mol. Psychiatry,2016
4. Transforming growth factor-β signaling in immunity and cancer.;Batlle;Immunity,2019
5. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies.;Bingle;J. Pathol.,2002
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献