Author:
Liu Yunnan,Wang Chen,Wei Mengying,Yang Guodong,Yuan Lijun
Abstract
Adipose tissue functions importantly in the bodily homeostasis and systemic metabolism, while obesity links to multiple disorders. Beyond the canonical hormones, growth factors and cytokines, exosomes have been identified to play important roles in transmission of information from adipose tissue to other organs. Exosomes are nanoscale membrane vesicles secreted by donor cells, and transfer the genetic information to the recipient cells where the encapsulated nucleic acids and proteins are released. In this review, we elaborate the recent advances in the biogenesis and profiling of adipose tissue derived exosomes, and their physiological and pathological effects on different organs. Moreover, the potential significance of the exosomes as therapeutic vehicles or drugs is also discussed.
Subject
Physiology (medical),Physiology
Reference79 articles.
1. Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications.;Ahmadi;J. Transl. Med.,2020
2. Extracellular vesicles in metabolic disease.;Akbar;Diabetologia,2019
3. Body adiposity index, body mass index, and body fat in white and black adults.;Barreira;JAMA,2011
4. Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality.;Britton;J. Am. Coll. Cardiol.,2013
5. Perivascular adipose tissue in vascular function and disease: a review of current research and animal models.;Brown;Arterioscler. Thromb. Vasc. Biol.,2014
Cited by
15 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献