Author:
Davis Amanda R.,Goodenough Chelsea G.,Westerlind Kim C.,Strange Robert,Deaver John W.,Ryan Patrick J.,Riechman Steven E.,Fluckey James D.
Abstract
Summary: There is strong evidence that physical activity has a profound protective effect against multiple types of cancer. Here, we show that this effect may be mediated by factors released from skeletal muscle during simulated exercise, in situ, which suppress canonical anabolic signaling in breast cancer. We report attenuated growth of MCF7 breast cancer cells in the presence of a rodent-derived exercise conditioned perfusate, independent of prior exercise training. This reduction was concomitant with increased levels of DEPTOR protein and reduced mTOR activity.
Funder
College of Education and Human Development, Texas A and M University
Sydney and J.L. Huffines Institute for Sports Medicine and Human Performance
Subject
Physiology (medical),Physiology
Cited by
3 articles.
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