Metabolic Diffusion in Neuropathologies: The Relevance of Brain-Liver Axis

Abstract

Graphical AbstractThe role of the liver in the metabolism of toxic compounds and in Aβ and α-synuclein clearance is related to neurological disorders such as Alzheimer’s Ddisease (AD) and Parkinson’s Disease (PD) development, although the supplementation with certain compounds may exert a protective effect. The current Western diet and alterations in the BA profile, whose homeostasis is controlled by the liver, have been also related to both AD and PD.