Using Salivary Biomarkers for Stress Assessment in Offshore Saturation Diving: A Pilot Study

Author:

Monnoyer Roxane,Lautridou Jacky,Deb Sanjoy,Hjelde Astrid,Eftedal Ingrid

Abstract

Health monitoring during offshore saturation diving is complicated due to restricted access to the divers, the desire to keep invasive procedures to a minimum, and limited opportunity for laboratory work onboard dive support vessels (DSV). In this pilot study, we examined whether measuring salivary biomarkrers in samples collected by the divers themselves might be a feasible approach to environmental stress assessment. Nine saturation divers were trained in the passive drool method for saliva collection and proceeded to collect samples at nine time points before, during, and after an offshore commercial saturation diving campaign. Samples collected within the hyperbaric living chambers were decompressed and stored frozen at −20°C onboard the DSV until they were shipped to land for analysis. Passive drool samples were collected without loss and assayed for a selection of salivary biomarkers: secretory immunoglobulin A (SIgA), C-reactive protein (CRP), tumor necrosis factor (TNF)-α, interleukins IL-6, IL-8, IL-1β, as well as cortisol and alpha-amylase. During the bottom phase of the hyperbaric saturation, SIgA, CRP, TNF-α, IL-8 and IL-1β increased significantly, whereas IL-6, cortisol and alpha-amylase were unchanged. All markers returned to pre-dive levels after the divers were decompressed back to surface pressure. We conclude that salivary biomarker analysis may be a feasible approach to stress assessment in offshore saturation diving. The results of our pilot test are consonant with an activation of the sympathetic nervous system related to systemic inflammation during hyperbaric and hyperoxic saturation.

Funder

Norwegian Research Council

Publisher

Frontiers Media SA

Subject

Physiology (medical),Physiology

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Oxy-Inflammation in Humans during Underwater Activities;International Journal of Molecular Sciences;2024-03-06

2. Evaluation of North Sea saturation procedures through divers monitoring;INT MARIT HEALTH;2024

3. Salivary Alpha-Amylase;Handbook of Assessment in Mindfulness Research;2023

4. Vascular Function Recovery Following Saturation Diving;Medicina;2022-10-17

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