Author:
Karavaev Anatoly S.,Ishbulatov Yurii M.,Prokhorov Mikhail D.,Ponomarenko Vladimir I.,Kiselev Anton R.,Runnova Anastasiia E.,Hramkov Alexey N.,Semyachkina-Glushkovskaya Oxana V.,Kurths Jürgen,Penzel Thomas
Abstract
We propose a mathematical model of the human cardiovascular system. The model allows one to simulate the main heart rate, its variability under the influence of the autonomic nervous system, breathing process, and oscillations of blood pressure. For the first time, the model takes into account the activity of the cerebral cortex structures that modulate the autonomic control loops of blood circulation in the awake state and in various stages of sleep. The adequacy of the model is demonstrated by comparing its time series with experimental records of healthy subjects in the SIESTA database. The proposed model can become a useful tool for studying the characteristics of the cardiovascular system dynamics during sleep.
Funder
Megagrants
Russian Science Foundation
Subject
Physiology (medical),Physiology
Reference54 articles.
1. Cardiac autonomic activity in obstructive sleep apnea time-dependent and spectral analysis of heart rate variability using 24-hour holter electrocardiograms.;Aydin;Tex. Heart Inst. J.,2004
2. Phase transitions in physiologic coupling.;Bartsch;Proc. Natl. Acad. Sci. U S A.,2012
3. Radial basis function neural networks for the characterization of heart rate variability dynamics.;Bezerianos;Artif. Intell. Med.,1995
4. An integrative model of respiratory and cardiovascular control in sleep-disordered breathing.;Cheng;RESPNB,2010
5. Neuro-endocrine regulation of blood pressure.;Chopra;Indian J. Endocrinol. Metab.,2011
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