Author:
Meirelles Marcela G.,Nornberg Bruna F.,da Silveira Tony L. R.,Kütter Mateus T.,Castro Caroline G.,Ramirez Juan Rafael B.,Pedrosa Virgínia,Romano Luis Alberto,Marins Luis Fernando
Abstract
Graphical AbstractGH overexpression increases the intestinal mass and absorptive surface area both through the direct effects of GH transgenics (up-regulating the expression of its cognate receptor and insulin-like growth factor, igf1a) and through indirect effects through an increase in the amount of food consumed. In addition, hyperphagia provides a greater amount of nutrients in the intestinal lumen and stimulates the synthesis of di- and tri-peptide transporters, which are the main route of absorption of dietary products from protein degradation.
Funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Subject
Physiology (medical),Physiology
Cited by
3 articles.
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