Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels
Author:
Funder
National Institutes of Health
Publisher
Frontiers Media SA
Subject
Physiology (medical),Physiology
Reference51 articles.
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2. Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome.;Anderson;Nat. Commun.,2014
3. Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane.;Apaja;Mol. Biol. Cell,2013
4. LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms.;Aromolaran;Cardiovasc. Res.,2014
5. Molecular pathophysiology of congenital long QT syndrome.;Bohnen;Physiol. Rev.,2016
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1. The proteostasis interactomes of trafficking-deficient variants of the voltage-gated potassium channel KV11.1 associated with long QT syndrome;Journal of Biological Chemistry;2024-07
2. The proteostasis interactomes of trafficking-deficient KV11.1 variants associated with Long QT Syndrome and pharmacological chaperone rescue;2024-01-31
3. Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants;Molecular Therapy - Nucleic Acids;2023-12
4. Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex;eLife;2023-08-31
5. Enhanced Ca 2+ -Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation;Circulation Research;2023-04-28
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