Author:
Saha Partha S.,Mayhan William G.
Abstract
Alcohol is a well-known teratogen, and prenatal alcohol exposure (PAE) leads to a greater incidence of many cardiovascular-related pathologies. Alcohol negatively impacts vasculogenesis and angiogenesis in the developing fetal brain, resulting in fetal alcohol spectrum disorders (FASD). Ample preclinical evidence indicates that the normal reactivity of cerebral resistance arterioles, which regulate blood flow distribution in response to metabolic demand (neurovascular coupling), is impaired by PAE. This impairment of dilation of cerebral arteries may carry implications for the susceptibility of the brain to cerebral ischemic damage well into adulthood. The focus of this review is to consolidate findings from studies examining the influence of PAE on vascular development, give insights into relevant pathological mechanisms at the vascular level, evaluate the risks of ethanol-driven alterations of cerebrovascular reactivity, and revisit different preventive interventions that may have promise in reversing vascular changes in preclinical FASD models.
Funder
National Institute on Alcohol Abuse and Alcoholism
Reference101 articles.
1. Alcohol use in pregnancy;Dejong;Clin Obstet Gynecol,2019
2. Declines in unintended pregnancy in the United States, 2008-2011;Finer;N Engl J Med,2016
3. Teratogenic effects of alcohol on brain and behavior;Mattson;Alcohol Res Health,2001
4. Impact of fetal alcohol exposure on body systems: a systematic review;Caputo;Birth Defects Res C Embryo Today,2016
5. Fetal alcohol spectrum disorders: from research to policy;Thomas;Alcohol Res Health,2010