Author:
Doi Miyuki,Li Mengwei,Usui Noriyoshi,Shimada Shoichi
Abstract
Recent breakthroughs in sequencing technology and technological developments have made it easier to analyze the entire human genome than ever before. In addition to disease-specific genetic mutations and chromosomal aberrations, epigenetic alterations in individuals can also be analyzed using genomics. Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) caused by genetic and/or environmental factors. More than a thousand genes associated with ASD have been identified which are known to be involved in brain development. However, it is difficult to decode the roles of ASD-associated genes without in vitro and in vivo validations, particularly in the process of brain development. In this review, we discuss genomic strategies for understanding the pathological mechanisms underlying ASD. For this purpose, we discuss ASD-associated genes and their functions, as well as analytical strategies and their strengths and weaknesses in cellular and animal models from a basic research perspective.
Funder
Japan Science and Technology Agency
Japan Society for the Promotion of Science
Uehara Memorial Foundation
Takeda Science Foundation
SENSHIN Medical Research Foundation
Osaka Medical Research Foundation for Intractable Diseases
Subject
Cellular and Molecular Neuroscience,Molecular Biology
Cited by
5 articles.
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