Author:
Chen Bin-Jun,Qian Xiao-qing,Yang Xiao-yu,Jiang Tao,Wang Yan-mei,Lyu Ji-han,Chi Fang-lu,Chen Ping,Ren Dong-dong
Abstract
Vestibular organs have unique planar cell polarity (Figure 1A), and their normal development and function are dependent on the regular polarity of cilia (Figure 1B) requires. Rab11a is a small G protein that participates in the transportation of intracellular and extracellular materials required for polarity formation; however, our understanding of the mechanisms of the actions of Rab11a in vestibular organs is limited. Here, we showed that the general shape of the utricle was abnormal in Rab11aCKO/CKO mice. These mice also showed abnormal morphology of the stereocilia bundles, which were reduced in both length and number, as well as disturbed tissue-level polarity. Rab11a affected the distribution of polarity proteins in the vestibular organs, indicating that the normal development of cilia requires Rab11a and intraflagellar transportation. Furthermore, small G protein migration works together with intraflagellar transportation in the normal development of cilia.
Funder
National Natural Science Foundation of China
Subject
Cellular and Molecular Neuroscience,Molecular Biology
Cited by
3 articles.
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