Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validation

Author:

Wang Yiran,Li Qianru,Xue Xiao'ao,Xu Xiaoyun,Tao Weichu,Liu Sixu,Li Yunyi,Wang He,Hua Yinghui

Abstract

BackgroundPain plays an important role in chronic ankle instability (CAI), and prolonged pain may be associated with ankle dysfunction and abnormal neuroplasticity.PurposeTo investigate the differences in resting-state functional connectivity among the pain-related brain regions and the ankle motor-related brain regions between healthy controls and patients with CAI, and explore the relationship between patients' motor function and pain.Study designA cross-database, cross-sectional study.MethodsThis study included a UK Biobank dataset of 28 patients with ankle pain and 109 healthy controls and a validation dataset of 15 patients with CAI and 15 healthy controls. All participants underwent resting-state functional magnetic resonance imaging scanning, and the functional connectivity (FC) among the pain-related brain regions and the ankle motor-related brain regions were calculated and compared between groups. The correlations between the potentially different functional connectivity and the clinical questionnaires were also explored in patients with CAI.ResultsThe functional connection between the cingulate motor area and insula significantly differed between groups in both the UK Biobank (p = 0.005) and clinical validation dataset (p = 0.049), which was also significantly correlated with Tegner scores (r = 0.532, p = 0.041) in patients with CAI.ConclusionA reduced functional connection between the cingulate motor area and the insula was present in patients with CAI, which was also directly correlated with reduction in the level of patient physical activity.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Natural Science Foundation of Shanghai

Science and Technology Commission of Shanghai Municipality

Publisher

Frontiers Media SA

Subject

Cellular and Molecular Neuroscience,Molecular Biology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Acute pain impairs retention of locomotor learning;Journal of Neurophysiology;2024-04-01

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