Severe chronic abuse of zolpidem for over 10 years: a case report and review of similar cases

Abstract

BackgroundInsomnia is a major health issue, and zolpidem is an effective treatment for insomnia. However, high doses of zolpidem can cause dependence, abuse, and withdrawal symptoms, questioning its advantages.Case presentationA 39-year-old woman who has been divorced and unemployed for 2 years was referred to an addiction treatment center with a chief complaint of “seizure-like withdrawal symptoms after consuming high doses of zolpidem (up to 6,000 mg per day) for a decade.” These symptoms were in the form of body tremors, nystagmus, stress, anxiety, hot flashes, and sweaty palms. She has been undergoing detoxification by clonazepam for almost 2 months. Except for the first few days, she did not have any withdrawal symptoms, and her insomnia caused by zolpidem has improved.ConclusionChronic abuse of zolpidem can cause dependence, withdrawal symptoms, and abuse. High doses can lead to extreme cravings and dependence. Physicians must manage the withdrawal process.