Author:
Yang Yuan,Zhang Shu-Fang,Yang Bing Xiang,Li Wen,Sha Sha,Jia Fu-Jun,Cheung Teris,Zhang De-Xing,Ng Chee H.,Xiang Yu-Tao
Abstract
BackgroundSymptoms of depression and pain often overlap, and they negatively influence the prognosis and treatment outcome of both conditions. However, the comorbidity of depression and pain has not been examined using network analysis, especially in the context of a pandemic. Thus, we mapped out the network connectivity among the symptoms of depression and pain in Wuhan residents in China during the late stage of the COVID-19 pandemic.MethodsThis cross-sectional study was conducted from May 25, 2020 to June 18, 2020 in Wuhan, China. Participants' depressive and pain symptoms were assessed using the 9-item Patient Health Questionnaire (PHQ9) and a pain numeric rating scale (NRS), respectively. Network analyses were performed.ResultsIn total, 2,598 participants completed all assessments. PHQ4 (fatigue) in the depression community showed the highest strength value, followed by PHQ6 (worthlessness) and PHQ2 (depressed or sad mood). PHQ4 (fatigue) was also the most key bridge symptom liking depression and pain, followed by PHQ3 (sleep difficulties). There were no significant differences in network global strength (females: 4.36 vs. males: 4.29; S = 0.075, P = 0.427), network structure-distribution of edge weights (M = 0.12, P = 0.541), and individual edge weights between male and female participants.ConclusionDepressive and pain symptoms showed strong cross-association with each other. “Fatigue” was the strongest central and bridge symptom in the network model, while “sleep difficulties” was the second strongest bridge symptom. Targeting treatment of both fatigue and sleep problems may help improve depressive and pain symptoms in those affected.
Subject
Psychiatry and Mental health
Reference63 articles.
1. SeattleIHMEInstitute Institute for Health Metric and Evaluation: Findings From the Global Burden of Disease Study2017
2. 2017
3. Depression, anxiety and acute pain: links and management challenges;Michaelides;Postgrad Med.,2019
4. Neuroplasticity underlying the comorbidity of pain and depression;Doan;Neural Plast.,2015
5. Depression and pain comorbidity: a literature review;Bair;Arch Intern Med.,2003
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献