Author:
Jia Huibin,Gao Fei,Yu Dongchuan
Abstract
Functional connectivity, quantified by phase synchrony, between brain regions is known to be aberrant in patients with autism spectrum disorder (ASD). Here, we evaluated the long-range temporal correlations of time-varying phase synchrony (TV-PS) of electrocortical oscillations in patients with ASD as well as typically developing people using detrended fluctuation analysis (DFA) after validating the scale-invariance of the TV-PS time series. By comparing the DFA exponents between the two groups, we found that those of the TV-PS time series of high-gamma oscillations were significantly attenuated in patients with ASD. Furthermore, the regions involved in aberrant TV-PS time series were mainly within the social ability and cognition-related cortical networks. These results support the notion that abnormal social functions observed in patients with ASD may be caused by the highly volatile phase synchrony states of electrocortical oscillations.
Subject
Psychiatry and Mental health
Reference44 articles.
1. Autism Diagnostic Observation Schedule (ADOS-2);Lord,2012
2. The Default Mode Network in Autism;Padmanabhan;Biol Psychiatry Cogn Neurosci Neuroimaging.,2017
3. Neuroanatomy of autism;Amaral;Trends Neurosci.,2008
4. Autism and abnormal development of brain connectivity;Belmonte;J Neurosci.,2004
5. Dynamic functional connectivity: Promise, issues, and interpretations;Hutchison;Neuroimage.,2013
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