Author:
Manusov Eron Grant,Diego Vincent P.,Sheikh Khalid,Laston Sandra,Blangero John,Williams-Blangero Sarah
Abstract
This study examines the impact of G × E interaction effects on non-alcoholic fatty liver disease (NAFLD) among Mexican Americans in the Rio Grande Valley (RGV) of South Texas. We examined potential G × E interaction using variance components models and likelihood-based statistical inference in the phenotypic expression of NAFLD, including hepatic steatosis and hepatic fibrosis (identified using vibration controlled transient elastography and controlled attenuation parameter measured by the FibroScan Device). We screened for depression using the Beck Depression Inventory-II (BDI-II). We identified significant G × E interactions for hepatic fibrosis × BDI-II. These findings provide evidence that genetic factors interact with depression to influence the expression of hepatic fibrosis.
Subject
Psychiatry and Mental health
Reference62 articles.
1. Depression, obesity, and metabolic syndrome: prevalence and risks of comorbidity in a population-based representative sample of Mexican Americans.;Olvera;J Clin Psychiatry.,2015
2. UniMóvil: a mobile health clinic providing primary care to the colonias of the Rio Grande Valley, South Texas.;Manusov;Front Public Health.,2019
3. Epidemiology, pathogenesis, diagnosis and emerging treatment of nonalcoholic fatty liver disease.;Makri;Arch Med Res.,2021
4. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention.;Younossi;Nat Rev Gastroenterol Hepatol.,2018
5. The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: a systematic review and meta-analysis.;Younossi;J Hepatol.,2019
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