Spatial memory deficits in Alzheimer’s disease and their connection to cognitive maps’ formation by place cells and grid cells

Author:

Silva Azul,Martínez María Cecilia

Abstract

Whenever we navigate through different contexts, we build a cognitive map: an internal representation of the territory. Spatial navigation is a complex skill that involves multiple types of information processing and integration. Place cells and grid cells, collectively with other hippocampal and medial entorhinal cortex neurons (MEC), form a neural network whose activity is critical for the representation of self-position and orientation along with spatial memory retrieval. Furthermore, this activity generates new representations adapting to changes in the environment. Though there is a normal decline in spatial memory related to aging, this is dramatically increased in pathological conditions such as Alzheimer’s disease (AD). AD is a multi-factorial neurodegenerative disorder affecting mainly the hippocampus-entorhinal cortex (HP-EC) circuit. Consequently, the initial stages of the disease have disorientation and wandering behavior as two of its hallmarks. Recent electrophysiological studies have linked spatial memory deficits to difficulties in spatial information encoding. Here we will discuss map impairment and remapping disruption in the HP-EC network, as a possible circuit mechanism involved in the spatial memory and navigation deficits observed in AD, pointing out the benefits of virtual reality as a tool for early diagnosis and rehabilitation.

Funder

Agencia Nacional de Promoción Científica y Tecnológica

Publisher

Frontiers Media SA

Subject

Behavioral Neuroscience,Cognitive Neuroscience,Neuropsychology and Physiological Psychology

Reference89 articles.

1. Impaired path integration and grid cell spatial periodicity in mice lacking GluA1-containing AMPA receptors.;Allen;J. Neurosci.,2014

2. The molecular biology of senile plaques and neurofibrillary tangles in Alzheimer’s disease.;Armstrong;Folia Neuropathol.,2009

3. Role of tau protein in both physiological and pathological conditions.;Avila;Physiol. Rev.,2004

4. Grid-like neural representations support olfactory navigation of a two-dimensional odor space.;Bao;Neuron,2019

5. Role of tau as a microtubule-associated protein: Structural and functional aspects.;Barbier;Front. Aging Neurosci.,2019

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3