Author:
Wu Qianwen,Peng Tingting,Liu Liru,Zeng Peishan,Xu Yunxian,Yang Xubo,Zhao Yiting,Fu Chaoqiong,Huang Shiya,Huang Yuan,Zhou Hongyu,Liu Yun,Tang Hongmei,He Lu,Xu Kaishou
Abstract
Constraint-induced movement therapy (CIMT) combined with repetitive transcranial magnetic stimulation (rTMS) have shown great potential in improving function in schoolchildren with unilateral cerebral palsy attributed to perinatal stroke. However, the prospect of application in preschool children with unilateral cerebral palsy (UCP) attributed to various brain disorders remains unclear. In this prospective, assessor-blinded, randomized controlled study, 40 preschool children with UCP (aged 2.5–6 years) were randomized to receive 10 days of CIMT combined with active or sham rTMS. Assessments were performed at baseline, 2 weeks, and 6 months post-intervention to investigate upper limb extremity, social life ability, and perceived changes by parents and motor-evoked potentials. Overall, 35 participants completed the trial. The CIMT plus active stimulation group had greater gains in the affected hand function (range of motion, accuracy, and fluency) than the CIMT plus sham stimulation group (P < 0.05), but there was no significant difference in muscular tone, social life ability, and perceived changes by parents between the two groups (P > 0.05). In addition, there was no significant difference in hand function between children with and without motor-evoked potential (P > 0.05). No participants reported severe adverse events during the study session. In short, the treatment of CIMT combined with rTMS is safe and feasible for preschool children with UCP attributed to various brain disorders. Randomized controlled studies with large samples and long-term effects are warranted.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangdong Province
Basic and Applied Basic Research Foundation of Guangdong Province
Guangzhou Municipal Science and Technology Project
Subject
Behavioral Neuroscience,Cognitive Neuroscience,Neuropsychology and Physiological Psychology
Cited by
4 articles.
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