Infantile-onset inflammatory bowel disease has variable long-term outcomes

Author:

Krauthammer Alex,Weintraub Ilana,Shaoul Ron,Lev-Tzion Raffi,Broide Efrat,Wilschanski Michael,Lerner Aaron,Yerushalmi Baruch,Shouval Dror S.,Shamaly Hussein,Haberman-Ziv Yael,Weiss Batia

Abstract

Objective and aimInfantile-onset inflammatory bowel disease (IO-IBD), defined as IBD diagnosed at age 2 years or younger, tends to be more severe and refractory to conventional treatment than IBD diagnosed at a later age. However, data about IO-IBD and its long-term follow up are limited. We thus aimed to evaluate the presentation and long-term outcomes of patients with IO-IBD in a retrospective multicenter study.MethodsMedical records of patients diagnosed with IO-IBD in eight medical centers during 2000–2017 with at least 1-year follow up were reviewed. Demographics and disease characteristics at diagnosis including age of onset, disease phenotype and location, surgeries, medical therapy, and comorbid conditions were recorded.ResultsTwenty-three patients with IO-IBD (16 males, 70%) were identified and followed for a median (range) of 51.2 (26.0–110.3) months. The mean ages at presentation and at the last follow up were 14 ± 9.8 and 101 ± 77 months, respectively. Six (26%) patients needed ileostomy already at the time of diagnosis and 20 (87%) were treated with corticosteroids. During long-term follow up, remission was achieved in 16 (73%) patients; of whom, 3 (14%) were without medications and 7 (32%) were in remission with the use of 5-aminosalicylic acid only. One patient needed hemicolectomy and one developed a severe EBV related infection.ConclusionThe majority of patients with IO-IBD achieved long-term remission, despite a severe disease presentation at diagnosis. Surgery rate however is high, mainly during the first months from diagnosis.

Publisher

Frontiers Media SA

Subject

Pediatrics, Perinatology and Child Health

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