Author:
Maddux Aline B.,Young Cameron C.,Kucukak Suden,Zambrano Laura D.,Newhams Margaret M.,Rollins Caitlin K.,Halasa Natasha B.,Gertz Shira J.,Mack Elizabeth H.,Schwartz Stephanie,Kong Michele,Loftis Laura L.,Irby Katherine,Rowan Courtney M.,Tarquinio Keiko M.,Zinter Matt S.,Crandall Hillary,Cvijanovich Natalie Z.,Schuster Jennifer E.,Fitzgerald Julie C.,Staat Mary A.,Hobbs Charlotte V.,Nofziger Ryan A.,Shein Steven,Flori Heidi,Cullimore Melissa L.,Chatani Brandon M.,Levy Emily R.,Typpo Katri V.,Hume Janet R.,Campbell Angela P.,Randolph Adrienne G.,
Abstract
ObjectiveTo identify risk factors for persistent impairments after pediatric hospitalization for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C) during the SARS-CoV-2 pandemic.MethodsAcross 25 U.S. Overcoming COVID-19 Network hospitals, we conducted a prospective cohort study of patients <21-years-old hospitalized for acute COVID-19 or MIS-C (May 2020 to March 2022) surveyed 2- to 4-months post-admission. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).ResultsOf 232 children with acute COVID-19, 71 (30.6%) had persistent symptoms and 50 (21.6%) had activity impairments at follow-up; for MIS-C (n= 241), 56 (23.2%) had persistent symptoms and 58 (24.1%) had activity impairments. In adjusted analyses of patients with acute COVID-19, receipt of mechanical ventilation was associated with persistent symptoms [aRR 1.83 (95% CI: 1.07, 3.13)] whereas obesity [aRR 2.18 (95% CI: 1.05, 4.51)] and greater organ system involvement [aRR 1.35 (95% CI: 1.13, 1.61)] were associated with activity impairment. For patients with MIS-C, having a pre-existing respiratory condition was associated with persistent symptoms [aRR 3.04 (95% CI: 1.70, 5.41)] whereas obesity [aRR 1.86 (95% CI: 1.09, 3.15)] and greater organ system involvement [aRR 1.26 (1.00, 1.58)] were associated with activity impairments.DiscussionAmong patients hospitalized, nearly one in three hospitalized with acute COVID-19 and one in four hospitalized with MIS-C had persistent impairments for ≥2 months post-hospitalization. Persistent impairments were associated with more severe illness and underlying health conditions, identifying populations to target for follow-up.
Subject
Pediatrics, Perinatology and Child Health
Cited by
1 articles.
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