Association Between MTHFR C677T Polymorphism and Susceptibility to Autism Spectrum Disorders: A Meta-Analysis in Chinese Han Population

Author:

Li Chen-Xi,Liu Yi-Guang,Che Yue-Ping,Ou Jian-Lin,Ruan Wen-Cong,Yu Yong-Lin,Li Hai-Feng

Abstract

Prior studies have examined the influence of MTHFR C677T on autism susceptibility, however, there are no consensus conclusions and specific analyses of a Chinese population. This meta-analysis included a false-positive report probability (FPRP) test to comprehensively evaluate the association of MTHFR C677T polymorphism with autism susceptibility among a Chinese Han population. A large-scale literature retrieval was conducted using various databases including PubMed, Embase, Wan Fang, and the Chinese National Knowledge Infrastructure (CNKI) up to July 31, 2020, with a total of 2,258 cases and 2,073 controls included. The strength of correlation was assessed by odds ratios (ORs) and 95% confidence intervals (95% CIs). MTHFR C677T showed a significant correlation with increased ASD susceptibility under all genetic models (T vs. C, OR = 1.89, 95% CI 1.28 to 2.79; TT vs. CC: OR = 2.44, 95% CI 1.43 to 4.15; CT vs. CC, OR = 1.73; 95% CI 1.19 to 2.51; CT + TT vs. CC: OR = 2.03, 95% CI 1.31 to 3.15; TT vs. CT + CC, OR = 1.95, 95% CI 1.21 to 3.13). Stratification analysis by region also revealed a consistent association in the Northern Han subgroup, but not in the Southern Han subgroup. Pooled minor allele frequency (MAF) of 30 studies were 45% in Northern Han and 39% in Southern Han. To avoid a possible “false positive report,” we further investigated the significant associations observed in the present meta-analysis using the FPRP test, which consolidated the results. In conclusion, MTHFR C677T polymorphism is associated with the increased risk of autism in China, especially in Northern Han. For those mothers and children who are generally susceptible to autism, prenatal folate and vitamin B12 may reduce the risk that children suffer from autism, especially in Northern Han populations. In the future, more well-designed studies with a larger sample size are expected.

Publisher

Frontiers Media SA

Subject

Pediatrics, Perinatology, and Child Health

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Metabolomic changes in children with autism;World Journal of Clinical Pediatrics;2024-06-09

2. MTHFR C677T Gene Polymorphism and Association with Disorders;WSEAS TRANSACTIONS ON BIOLOGY AND BIOMEDICINE;2024-03-14

3. GENE MTHFR C677T (rs1801133) E SUSCETIBILIDADE AO TRANSTORNO DO ESPECTRO AUTISTA (TEA);RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218;2024-02-10

4. Methylenetetrahydrofolate Reductase Gene Polymorphism as a Risk Factor for Coronary Artery Disease;Indian Journal of Clinical Biochemistry;2023-11-23

5. Folate–Methionine Cycle Disruptions in ASD Patients and Possible Interventions: A Systematic Review;Genes;2023-03-13

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