Spondyloarthritides: Theories and beyond

Author:

Kocatürk Begüm,Balık Zeynep,Pişiren Gaye,Kalyoncu Umut,Özmen Füsun,Özen Seza

Abstract

Spondyloarthritides (SpA) are a family of interrelated rheumatic disorders with a typical disease onset ranging from childhood to middle age. If left untreated, they lead to a severe decrease in patients' quality of life. A succesfull treatment strategy starts with an accurate diagnosis which is achieved through careful analysis of medical symptoms. Classification criterias are used to this process and are updated on a regular basis. Although there is a lack of definite knowledge on the disease etiology of SpA, several studies have paved the way for understanding plausible risk factors and developing treatment strategies. The significant increase of HLA-B27 positivity in SpA patients makes it a strong candidate as a predisposing factor and several theories have been proposed to explain HLA-B27 driven disease progression. However, the presence of HLA-B27 negative patients underlines the presence of additional risk factors. The current treatment options for SpAs are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), TNF inhibitors (TNFis), Disease-Modifying Anti-Rheumatic Drugs (DMARDs) and physiotherapy yet there are ongoing clinical trials. Anti IL17 drugs and targeted synthetic DMARDs such as JAK inhibitors are also emerging as treatment alternatives. This review discusses the current diagnosis criteria, treatment options and gives an overview of the previous findings and theories to clarify the possible contributors to SpA pathogenesis with a focus on Ankylosing Spondylitis (AS) and enthesitis-related arthritis (ERA).

Publisher

Frontiers Media SA

Subject

Pediatrics, Perinatology and Child Health

Reference183 articles.

1. Spondyloarthropathies: an overview;Stafford;Intern Med J,2002

2. International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001;Petty;J Rheumatol,2004

3. Treatment prescribing patterns in patients with Juvenile Idiopathic Arthritis (JIA): analysis from the UK Childhood Arthritis Prospective Study (CAPS);Davies;Semin Arthritis Rheum,2016

4. The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-out cohort;Guzman;Ann Rheum Dis,2015

5. Paediatric rheumatology clinic population in Southeast Asia: are we different?;Arkachaisri;Rheumatology,2017

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