Nutritional Supplementation to Increase Influenza Vaccine Response in Children Living With HIV: A Pilot Clinical Trial

Author:

Sainz Talía,Casas Inmaculada,González-Esguevillas Mónica,Escosa-Garcia Luis,Muñoz-Fernández María Ángeles,Prieto Luis,Gosalbes María José,Jiménez-Hernández Nuria,Ramos José Tomas,Navarro María Luisa,Mellado María José,Serrano-Villar Sergio,Calvo Cristina

Abstract

AimsVaccine response is poor among children living with HIV. The gut microbiota has been identified as a potential target to improve vaccine immunogenicity, but data are scarce in the context of HIV infection.MethodsPilot, double-blind, randomized placebo-controlled trial in which 24 HIV-infected children were randomized to receive a mixture of symbiotics, omega-3/6 fatty acids, and amino acids or placebo for 4 weeks, each in combination with ART, and were then immunized against influenza. Vaccine response and safety of the nutritional supplementation were the primary outcomes.ResultsEighteen HIV-infected children completed the follow-up period (mean age 11.5 ± 4.14 years, 61% female). The nutritional supplement was safe but did not enhance the response to the influenza vaccine. A 4-fold rise in antibody titers was obtained in only 37.5% of participants in the intervention arm vs. 40% in the placebo. No immunological or inflammatory predictors of vaccine response were identified.ConclusionsIn this exploratory study, a 4-week course of symbiotics did not increase influenza vaccine immunogenicity in HIV-infected children. Larger studies are warranted to address the potential of modulating the microbiome in children living with HIV.

Funder

Instituto de Salud Carlos III

Publisher

Frontiers Media SA

Subject

Pediatrics, Perinatology and Child Health

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