Author:
Radhakrishnan Rupa,Vishnubhotla Ramana V.,Zhao Yi,Yan Jingwen,He Bing,Steinhardt Nicole,Haas David M.,Sokol Gregory M.,Sadhasivam Senthilkumar
Abstract
BackgroundInfants with prenatal opioid and substance exposure are at higher risk of poor neurobehavioral outcomes in later childhood. Early brain imaging in infancy has the potential to identify early brain developmental alterations that may help predict behavioral outcomes in these children. In this study, using resting-state functional MRI in early infancy, we aim to identify differences in global brain network connectivity in infants with prenatal opioid and substance exposure compared to healthy control infants.Methods and MaterialsIn this prospective study, we recruited 23 infants with prenatal opioid exposure and 29 healthy opioid naïve infants. All subjects underwent brain resting-state functional MRI before 3 months postmenstrual age. Covariate Assisted Principal (CAP) regression was performed to identify brain networks within which functional connectivity was associated with opioid exposure after adjusting for sex and gestational age. Associations of these significant networks with maternal comorbidities were also evaluated. Additionally, graph network metrics were assessed in these CAP networks.ResultsThere were four CAP network components that were significantly different between the opioid exposed and healthy control infants. Two of these four networks were associated with maternal psychological factors. Intra-network graph metrics, namely average flow coefficient, clustering coefficient and transitivity were also significantly different in opioid exposed infants compared to healthy controls.ConclusionPrenatal opioid exposure is associated with alterations in global brain functional networks compared to non-opioid exposed infants, with intra-network alterations in graph network modeling. These network alterations were also associated with maternal comorbidity, especially mental health. Large-scale longitudinal studies can help in understanding the clinical implications of these early brain functional network alterations in infants with prenatal opioid exposure.
Funder
Eunice Kennedy Shriver National Institute of Child Health and Human Development
American Roentgen Ray Society
Radiological Society of North America
Subject
Pediatrics, Perinatology and Child Health
Reference74 articles.
1. Vital signs: prescription opioid pain reliever use during pregnancy — 34 U.S. jurisdictions, 2019;Ko;Cent Dis Cont Prev MMWR.,2020
2. Increase in prescription opioid use during pregnancy among medicaid-enrolled women;Desai;Obstet Gynecol.,2014
3. Vital signs: overdoses of prescription opioid pain relievers—United States, 1999–2008;MMWR Morb Mortal Wkly Rep,2011
4. Increases in heroin overdose deaths - 28 States, 2010 to 2012;Rudd;MMWR Morb Mortal Wkly Rep.,2014
5. Deaths involving fentanyl, fentanyl analogs, and U-47700 - 10 states, July-December 2016;O'Donnell;MMWR Morb Mortal Wkly Rep.,2017
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献