Author:
Sieber Justyna,Renner Sabine,Lakatos-Krepcik Andrea,Szépfalusi Zsolt
Abstract
Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce. Based on an IgE-mediated colomycin allergy we describe the maintenance of drug tolerance to nebulized drug for the period of 10 years in a 15-year-old cystic fibrosis patient, proceeded by successful rush intravenous desensitization protocol. The mechanism of drug tolerance is largely speculative; however, long-term maintenance of it seems achievable by continuous local drug application.
Subject
Pediatrics, Perinatology, and Child Health
Cited by
3 articles.
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